I'm not sure if the numbers actually mean anything outside of the world of Lost, but they (as a group of numbers, not the individuals) have a pretty large significance.
I'll gladly watch the next season. The last episode really was creepy, though I felt bad for laughing at Arzt's mishap.
As for the weird people on the boat, it's really a curious thing. I think the writers are just using them to throw people off by making it seem as if they come from the outside. I think they come from the island itself.
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I never had any doubt that they came for the Island. They knew the boy had left the Island and were searching for him.